Study [ADMIT_01] study / subjects / design / samples / assays

Basic properties of your study This page shows the basic information about your study, as well as information on the authorizations.

Publications

Contacts

  • Ernst, Robert
    Data Submission
  • Coolen, Jordy
    Data Submission

Authorization

Public Design
Yes
Readers
remon.dulos
tim.vandenbroek
joost.westerhout
everton.soutolima
lodewic.vantwillert
willem.vandenbrink
ben.vanommen
annemarie.prins
serdar.ozsezen
peter.wielinga
everton.lima
andre.boorsma
eugene.vansomeren
martien.caspers
lars.verschuren
tno.user
wouter.zirkzee
pol.grootswagers
heleen.deweerd
rosario.lombardo
annelies.dijk
paula.santos
jildau.bouwman
herman.wietmarschen
femke.hoevenaars
suzan.wopereis
marjan.vanerk
ferry.jagers
Writers
Study title
Assessment of Dietary Modulation of Inflammatory Tone (ADMIT)
Template
Intervention/Observation study
title
Assessment of Dietary Modulation of Inflammatory Tone (ADMIT)
description
The kinetic responses of three different dietary challenges and a water control challenge were assessed on various metabolic and inflammatory markers in 14 healthy males and females using a full cross-over study design. The dietary challenges included glucose (75 g glucose in 300 ml water), lipids (200 ml whipping cream) and a mix of glucose and lipids (same amounts as above), respectively. Blood samples were collected at baseline and at 0.5, 1, 2, 4, 6, 8 and 10 h after consumption of the treatment products. Inflammation (IFN(gamma), IL-1(beta), IL-6, IL-8, IL-10, IL-12p70, TNF-(alpha), CRP, ICAM-1, VCAM-1, SAA, E-selectin, P-selectin, thrombomodulin, leukocytes, neutrophils, lymphocytes) and clinical (e.g. glucose, insulin, triglycerides) markers as well as gene expression in blood cells and plasma oxylipin profiles were measured.
code
ADMIT_01
startDate
2012-12-14 00:00:00.0
Study type
Human Intervention
Objectives
etsa
Central conclusion
This study shows that dietary glucose and lipid challenges hardly induced an acute inflammatory response in healthy subjects, as quantified by an accurate and broad panel of parameters.
Consortium
not defined

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