Study [ADMIT_01] study / subjects / design / samples / assays

Basic properties of your study This page shows the basic information about your study, as well as information on the authorizations.

Publications

Contacts

  • Coolen, Jordy
    Data Submission
  • Ernst, Robert
    Data Submission

Authorization

Public Design
Yes
Readers
andre.boorsma
eugene.vansomeren
jildau.bouwman
tno.user
juri.matualatupauw
everton.lima
peter.wielinga
joost.westerhout
martien.caspers
dulce.calcada
annelies.dijk
suzan.wopereis
heleen.deweerd
ben.vanommen
rosario.lombardo
ferry.jagers
herman.wietmarschen
annemarie.prins
lars.verschuren
marjan.vanerk
iris.dehoogh
tim.vandenbroek
everton.soutolima
remon.dulos
paula.santos
pol.grootswagers
willem.vandenbrink
TNO
Writers
Study title
Assessment of Dietary Modulation of Inflammatory Tone (ADMIT)
Template
Intervention/Observation study
title
Assessment of Dietary Modulation of Inflammatory Tone (ADMIT)
description
The kinetic responses of three different dietary challenges and a water control challenge were assessed on various metabolic and inflammatory markers in 14 healthy males and females using a full cross-over study design. The dietary challenges included glucose (75 g glucose in 300 ml water), lipids (200 ml whipping cream) and a mix of glucose and lipids (same amounts as above), respectively. Blood samples were collected at baseline and at 0.5, 1, 2, 4, 6, 8 and 10 h after consumption of the treatment products. Inflammation (IFN(gamma), IL-1(beta), IL-6, IL-8, IL-10, IL-12p70, TNF-(alpha), CRP, ICAM-1, VCAM-1, SAA, E-selectin, P-selectin, thrombomodulin, leukocytes, neutrophils, lymphocytes) and clinical (e.g. glucose, insulin, triglycerides) markers as well as gene expression in blood cells and plasma oxylipin profiles were measured.
code
ADMIT_01
startDate
2012-12-14 00:00:00.0
Study type
Human Intervention
Objectives
etsa
Central conclusion
This study shows that dietary glucose and lipid challenges hardly induced an acute inflammatory response in healthy subjects, as quantified by an accurate and broad panel of parameters.
Consortium
not defined

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