description
This study is part of the MEATIC project. The project is aimed at evaluating the role of gut microbiota in the correlation between diet (especially read meat consumption) and colorectal cancer (CRC). To this aim, the project is divided into 4 WPs on different experimental models or on cohort of healthy humans, but with a common dietary intervention design. In detail, the dietary intervention was structured in 3 classes: 1) red meat rich diet (high risk); 2) red meat rich diet with tocopherol (controlled risk class); 3) pesco-vegetarian diet (low risk). This study collects metadata and data of the WP4 of the MEATIC project. End-point of the project is to evaluate the fecal microbiota and the fecal metabolome, as well as different parameters connected to CRC and tumorigenesis, connected to different diet interventions. The subject of the dietary intervention in this study was a germ free rat model (F344). Gut microbiota was firstly inoculated by fecal microbiota transplant using feces sampled from experimental animals of the WP3 of the MEATIC project, after dietary intervention. Carcinogenesis was then chemically induced with Azoxymethane (AOM).
