Study [LIPGENE] study / subjects / design / samples / assays

Basic properties of your study This page shows the basic information about your study, as well as information on the authorizations.

Publications

  • Effects of dietary fat modification on insulin sensitivity and on other risk factors of the metabolic syndrome--LIPGENE: a European randomized dietary intervention study.
    Tierney AC, McMonagle J, Shaw DI, Gulseth HL, Helal O, Saris WH, Paniagua JA, Gołąbek-Leszczyñska I, Defoort C, Williams CM, Karsltröm B, Vessby B, Dembinska-Kiec A, López-Miranda J, Blaak EE, Drevon CA, Gibney MJ, Lovegrove JA, Roche HM
  • LIPGENE: an integrated approach to tackling the metabolic syndrome.
    Buttriss J, Nugent A
  • Lipoprotein profile, plasma ischemia modified albumin and LDL density change in the course of postprandial lipemia. Insights from the LIPGENE study.
    Hartwich J, Leszczynska-Golabek I, Kiec-Wilk B, Siedlecka D, Pérez-Martinez P, Marin C, López-Miranda J, Tierney A, Monagle JM, Roche HM, Defoort C, Wolkow P, Dembinska-Kiec A
  • A low-fat high-carbohydrate diet supplemented with long-chain n-3 PUFA reduces the risk of the metabolic syndrome.
    Paniagua JA, Pérez-Martinez P, Gjelstad IM, Tierney AC, Delgado-Lista J, Defoort C, Blaak EE, Risérus U, Drevon CA, Kiec-Wilk B, Lovegrove JA, Roche HM, López-Miranda J, LIPGENE Study Investigators

Contacts

  • Ryan, Miriam
    Data Submission

Authorization

Public Design
Yes
Readers
helen.roche
catherine.phillips
Writers
rosario.lombardo
miriam.ryan
Study title
LIPGENE: European randomized dietary intervention study
Template
Intervention/Observation study
title
LIPGENE: European randomized dietary intervention study
description
EU FP6 Integrated Programme conducted by a Consortium of 25 European research centres (2004-2009) Contract: FOOD-CT-2003-505944. Intervention study conducted by 8 centres. Subjects receive 1 of 4 Diets; A high fat SFA rich diet (HSFA), A high-fat MUFA-rich diet (HMUFA), An isoenergetic low-fat high complex carbohydrate Diet (LFHCC), An isoenergetic low-fat, high-complex carbohydrate diet with VLC n-3 PUFA (LFHCC n-3)
code
LIPGENE
startDate
2004-01-01 00:00:00.0
Study type
Human Intervention
Principle Investigator
PROF. HELEN ROCHE (UCD, Dublin)
Objectives
LIPGENE was a pan-European, multicentre dietary intervention study with 500 subjects designed to determine the relative efficacy of altering the quality and quantity of dietary fat on insulin sensitivity and metabolic risk factors associated with the Metabolic Syndrome. This was an isoenergetic intervention to exclude the effects of weight change.
Exclusion criteria
Age: < 35 or >70years Diabetes or other endocrine disorders (Diabetes (Type 1 and 2), Hypothyroidism, Hyperthyroidism, Adrenal disorders, Addisons Disease, Cushings Disease, Pheochromocytomas, Mulitiple Endocrine Neoplasia (MENS), other rare conditions as encountered) Chronic inflammatory conditions (Inflammatory Bowel Disease, Crohn’s Disease, Ulcerative Colitis, Rheumatoid Arthritis, Lupus, Atopic Dermatitis, Psoriasis, Coeliac Disease, Fibromyalgia, Pelvic Inflammatory Disease, Endometriosis, Asthma (on regular anti inflammatory medication), other rare conditions encountered) Kidney or liver dysfunction. Iron deficiency anaemia (haemoglobin < 12g/dl men, < 11g/dl women) Prescribed hypolipidaemic medication1 Prescribed anti-inflammatory medication Fatty acid supplements including fish oils, evening primrose oil, etc. Consumers of high doses of antioxidant vitamins (A, C, E, -carotene) Red rice yeast (Monascus purpureus) supplement usage. High consumers of oily fish (> 2 serving of oily fish per week of herring, mackerel, kippers, pilchards, sardines, salmon, trout, tuna (fresh), crabmeat or marlin). One portion is defined as a small herring or mackerel, one can of salmon or sardines or one salmon or tuna steak. Tinned tuna is permitted as it contains low amounts of n-3 PUFA. Highly trained or endurance athletes or those who participate in more than 3 periods of intense exercise per week. Volunteers planning to start a special diet or loose weight (e.g. the Slimfast Plan, Atkins Diet etc). Weight change equal or >3kg within the last 3 months. Alcohol or drug abuse (based on clinical judgement). Pregnant / lactating females / women planning a pregnancy in the next 12 months. Women who become pregnant during the dietary intervention period should be removed from the study.
Inclusion criteria
Age: 35 -70 years Gender: males and females (not pregnant or lactating). Body Mass Index (BMI) 20-40 kg/m2 Total cholesterol concentration equal to or < 8.0 mmol/l. Medications / nutritional supplements allowed, on condition that the subjects adhered to the same regimen during the intervention: anti-hypertensive medication (including beta-blockers), oral contraceptives, hormone replacement therapy, multi-vitamin supplements, other non-fatty acid based nutritional supplements Smokers and non-smokers. Regular consumers of alcohol, which was not excessive as defined by AST/ALT Ethnicity: Intention to include white Europeans.
Institute
Eight intervention centres UCD Dublin Ireland Reading, UK Oslo, Norway Marseille, France Maastricht, The Netherlands Cordoba, Spain Krakow, Poland Uppsala, Sweden
Collaborators involved
PROF. MIKE GIBNEY, Dr. CATHERINE PHILLIPS
Diet short codes and descriptions

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