description
The kinetic responses of three different dietary challenges and a water
control challenge were assessed on various metabolic and inflammatory markers in
14 healthy males and females using a full cross-over study design. The dietary
challenges included glucose (75 g glucose in 300 ml water), lipids (200 ml whipping
cream) and a mix of glucose and lipids (same amounts as above), respectively.
Blood samples were collected at baseline and at 0.5, 1, 2, 4, 6, 8 and 10 h after
consumption of the treatment products. Inflammation (IFN(gamma), IL-1(beta), IL-6, IL-8, IL-10, IL-12p70, TNF-(alpha), CRP, ICAM-1, VCAM-1, SAA, E-selectin, P-selectin,
thrombomodulin, leukocytes, neutrophils, lymphocytes) and clinical (e.g. glucose,
insulin, triglycerides) markers as well as gene expression in blood cells and plasma
oxylipin profiles were measured.
